Chance and necessity in cellular response to challenge
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چکیده
منابع مشابه
Chance and necessity in cellular response to challenge
Living cells are enormously elaborate and exquisitely finetuned molecular machines, and the way they respond to changes in the environment is precisely determined by the iron logic of adaptation. Or so we would like to believe should we stick to the traditional adaptationist paradigm of neo-Darwinism (Dobzhansky 1951; Mayr 1963). Of course, the foundations of neo-Darwinism have been shaken a lo...
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By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence siz...
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Charles Darwin has proposed the theory that evolution of live organisms is based on random variation and natural selection. Jacques Monod in his classic book Chance and Necessity, published 40 years ago, presented his thesis "that the biosphere does not contain a predictable class of objects or events, but constitutes a particular occurrence, compatible indeed with the first principles, but not...
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From the early 1920s, Europe was furiously struggling with the invasion of the Colorado potato beetle and then soon took cognisance of its inevitable triumph with resignation. All over Europe, laboratories were established and talented entomologists attempted to discover the “Achilles-heel” of the new pest devastating potato fields and threatening the potato industry. In 1947, the first scouts ...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2007
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100152